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How America Can Save the Smaller IPO

By: | February 24, 2015 | No Comments

In my last post, which grew out of my keynote conversation at the 2014 SNS Predictions Dinner, I touched on the sea-change that has occurred in the IPO market since the year 2000, where the smaller IPO of, say Intel in 1971, has given way to the mega IPOs of Google and Uber.


Why We Need to Go Back to the Small IPO

By: | February 17, 2015 | No Comments

When Intel went public in 1971, it wasn’t the behemoth that it is today. It was a tiny little company raising a very little bit of money in a public offering. Same with Amgen, or Genentech. Today they’re monster companies, built over 30- to 40-year time periods, but their initial public offerings (IPOs) were relatively small.


Technologies that Will Drive Innovation and Investing in 2015

By: | October 14, 2014 | No Comments

At Harris and Harris Group (H&H), a considerable amount of our time focuses on tracking the latest science and promising new technologies. To improve our chances of succeeding in early stage investing, we regularly meet and discuss new scientific discoveries that have been announced, with an eye to identifying investment opportunities that will mature over the next three to seven years.


Why BIOLOGY+ Offers a Fertile Field for Early Stage Investing

By: | October 8, 2014 | No Comments

Many of the “big problems” we face in this world — hunger, water, energy, health, climate change — are complex ones that are not going to be solved by any one discipline or industry alone. Solutions to such problems require an integrated and interdisciplinary approach.


The Death of the Hypothesis, or, Investing in Big Data Analytics and Deep Learning

By: | September 23, 2014 | No Comments

Over the last 24 months, I have been observing a profound shift in how we learn about the world. Barely noticeable at first, the newborn techniques are now roaring with multiple success cases and a promise to accelerate the pace of discovery dramatically.


The Opportunities for Outsized Returns in Early Stage Investing

By: | August 26, 2014 | No Comments

What if we could go back in time, and I gave you an opportunity to make an early stage investment in the Harris & Harris Group portfolio company BioVex, right as it was being founded? BioVex developed a new potential treatment for cancer and was purchased by Amgen in 2011 for up to $1 billion….


Taking a Very Different Approach to Early Stage Investing

By: | August 12, 2014 | No Comments

I was discussing our investment in Metabolon with someone recently, when I realized how well Metabolon exemplifies our unique approach to early stage investing. There is a tendency in the venture capital world to follow, lemming-like, into copy-cat deals that target whatever happens to be the hot industry — social media being the latest example….


H&H on the Cutting Edge: Enumeral Harnesses the Human Immune System on a Single Cell Level

By: | August 4, 2014 | No Comments

Harris & Harris Group is proud to be on the cutting edge of science and business as we build transformative companies enabled by disruptive science. We have produced a series of blogs illustrating how our companies are on the cutting edge of innovation and market trends. This post on Enumeral is our eighth blog in…


Why Smart Money Invests in the New York City Life Sciences Entrepreneurial Ecosystem

By: | July 29, 2014 | No Comments

While successful early stage investing is something we pride ourselves on at Harris & Harris Group, we’re always thinking creatively about better ways to find and build companies that fit our Biology+ focus. That’s why I’m especially excited about the recent announcement of the New York City expansion of Accelerator Corporation, an investment vehicle for…


Getting in on the Ground Floor: Investing in Quantum Computing

By: | July 8, 2014 | No Comments

There’s been a lot of excitement building recently about D-Wave Systems. You probably saw the Time Magazine article or perhaps the more recent Wired article on D-Wave’s progress in building a quantum computer. Both magazines take a pretty balanced look at the promise that D-Wave holds for the world and the questions that remain to…